Ryan Orbuch @orbuch
unlearned helplessness | partner @lowercarbon, previously @stripe sf Joined December 2011-
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Congratulations to Nan and @incredutility! Nan has a special gift for converting big abstract problem spaces into projects that feel extremely obvious in hindsight + the fundraising/recruiting ability to make them happen. A true GM: if you get a cold now you can blame her.
Today we're launching Intercept: a $500M philanthropic initiative to make respiratory infections, like the common cold and flu, a thing of the past. We treat respiratory infections as a minor nuisance, but that’s really not the case. Most of us will spend 5% of our lives (!)
Today we're launching Intercept: a $500M philanthropic initiative to make respiratory infections, like the common cold and flu, a thing of the past. We treat respiratory infections as a minor nuisance, but that’s really not the case. Most of us will spend 5% of our lives (!) sick from these viruses, they kill 1M people a year, cost $600B annually in productivity, and periodically threaten civilization through pandemics. So, if they’re such a big problem, why haven’t we dealt with them yet? Last year we convened ~40 leading scientists, pharma R&D leaders, biotech investors, and regulatory experts to better understand that. We heard two main reasons: (1) First, it’s just technically very challenging: respiratory viruses represent hundreds of distinct, mutating strains across several families. Fortunately, recent breakthroughs make this newly possible. (2) Second is a lack of funding: broad-spectrum solutions have historically been underfunded, in part because they’re not a great fit for most philanthropic or commercial funding (and while COVID generated a burst of activity around preventing and understanding respiratory infections through an influx of new funding, that hasn't been sustained). We think that with enough focus and funding, this might be solvable. Intercept is a $500 million philanthropic initiative that will take advantage of new tools to catalyze the development and deployment of two types of products: broad-spectrum preventatives and air cleaning technologies. This problem is undoubtedly difficult. But it’s more tractable now than it’s ever been. We think we should give it our best shot. We’re enormously grateful to our anchor funders: @stripe, @AnthropicAI, @TheFluLab, @FoundationOAI and individuals from Jane Street. And, I’m very excited to be building this with @incredutility and the rest of the team.
I joined @Stripe in January to build a new philanthropic initiative with @nanransohoff. Today we’re announcing Intercept, a $500m innovation fund focused on radically reducing the burden of respiratory viruses. I’ve spent the past decade investing in vaccines and drugs for infectious disease, and this is the most exciting thing I’ve ever been a part of. Thrilled to be working with @Stripe, @AnthropicAI, @TheFluLab, @FoundationOAI, @coeff_giving and individuals from Jane Street. We've raised the capital and now it’s time to get to work.
Today we're launching Intercept: a $500M philanthropic initiative to make respiratory infections, like the common cold and flu, a thing of the past. We treat respiratory infections as a minor nuisance, but that’s really not the case. Most of us will spend 5% of our lives (!)
i wish i could do more - i wish i had a thousand hands and a thousand eyes and a thousand years and army of angels and a thousand stars that lit the sky so bright that the night would never come and that our sleepless dreams would fill this world
Delighted to share that Frontier has raised an additional $915 million to accelerate the world’s best carbon removal companies. frontierclimate.com/writing/growth…
The modern world is predominantly a result of both lack of control and an abdication of responsibility, rather than particularly malevolent control.
Really neat new tool by the folks at @IFP to help find the best funding mechanism based on the problem you're trying ot solve.
At @IFP, we’ve spent the past 3 years thinking about all the different ways the US government & philanthropy fund R&D. Until now, R&D funders haven’t had a systematic way to match the innovation problem to the right funding tool. We built THE ATLAS OF INNOVATION to fill that
Documentary recapping Rainmaker's historic accomplishment for the Great Salt Lake this past winter We are the first company to repeatedly prove we're making it snow The care, toil, and brilliance of our team was heroic But we still need more water, the jobs not finished
New blog post: The third wave of American philanthropy Hundreds of billions of dollars in new philanthropic capital will soon become liquid. The OpenAI Foundation holds 26% of OpenAI, worth about $220B at today’s valuation. Anthropic’s seven co-founders have pledged to give away 80% of their wealth and have instituted the most aggressive donor matching program for employees in tech history. How much does this all add up to? And how meaningful is that in the context of philanthropy today? I was doing some simple napkin math to wrap my head around the scale of what’s coming, and radicalized myself in the process. I had dramatically underappreciated the scale of the philanthropic capital that’s about to become available and the corresponding gap in talent and organizations that will be needed to make the most of it. This piece aims to directionally sketch the scale of what’s coming, the gap in operational capacity needed to absorb it, and what we can do to fill it. (Link to full post in reply)
Climate activists have spent decades shutting down nuclear, blocking clean energy transmission, and trying to ban research on cooling the planet... but the movement that wins the next century will be led by the people doing the work, not those protesting it. New essay out today👇
great success had with no fatalities on this the second annual Nebular Deep Dive freediving excursion
Today we're announcing @_panthalassa’s $140M Series B, led by Peter Thiel, with participation from John Doerr and many other incredible investors. The mission: unlock the ocean as another planetary-scale energy resource for humanity. First stop: compute.
We should fund and build more organizations that are meant to solve problems - instead of working on them. New essay.
1/ @OctopusEnergy is backing Living Carbon with $500M to reforest degraded land and remove CO₂ across North America. This major project financing comes with an additional ~$13M investment in our carbon business. Living Carbon is putting low quality land back to work. Our innovative reforestation turns low quality land into thriving forests faster to remove carbon or produce sustainable forest products. Read more about it in today’s @WSJ (link in the comments) →
Mankind has always been at the mercy of the weather. No longer. Rainmaker is the first company in history to routinely, unambiguously, modify the weather. Last quarter, we produced >143MM gallons of unambiguously man-made precipitation. Here’s how we do it 🧵
In spite of how I present myself on the internet (unhinged, slightly feral) I do Real Work on Cool Things in Various Places and have published a new post to revive my substack / push myself to talk about this more. Link in next post to game the algorithm 👇
excellent as usual from @hollyjeanbuck, Actual Understander Of The Thing People Are Being Crazy About
Oh my God this is so good
So, @_panthalassa operated mostly in secret for a decade. And what it built is nuts. Massive, massive floating data centers that drive themselves out to sea and then capture water inside of them to spin a turbine and power GPUs. Look at these things. Full episode on the tech here youtube.com/watch?v=Q4PCJR…
A couple years ago the Ulysses team wheeled a tub of water and their first robot into our SF office. They said they would give humanity the tools to unlock the ocean frontier. They’re making good on that promise. Grateful to have backed them since the beginning 🦈
Ulysses has raised $46M led by a16z American Dynamism. We are building The Ocean Company. The ocean is 71% of the planet. But it is less explored than Mars, and full of secrets, waiting to be told. It is the backbone of global defense. Home to the critical infrastructure that
Jesse D. Jenkins @JesseJenkins
105K Followers 11K Following Professor of Energy Systems Engineering & Policy @EPrinceton & @AndlingerCenter. Co-founder Firma Power. Advisor to climate tech companies & investors.
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Jack Andreasen Cavana... @AndreasenJack
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Christian Larsen @calarsenc
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David Mayilian @mayiliand
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265 Followers 3K Following Voted for DJT in 2020. Anti-crime, pro-welfare state, pro-business. Want hella middle class family life, want cures for cancers + other illnesses
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The Artist fka: 𝓶�... @myceliummage
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Lexur @Lexur
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Sriram Krishnan @sriramk
310K Followers 3K Following https://t.co/VIQU0kxbhH. ex-white house, a16z and more. pro wrestling fan.
russell @russellromney
428 Followers 3K Following building filesystems for agents. build housing, touch grass. lower txn costs= ⬆️everything
Nil @Nil053
174 Followers 1K Following CS PhD · SWE · author · https://t.co/GKmAmVKcQq: give your agents a cute office · https://t.co/Zv8BSH4awd: prep leetcode · https://t.co/HjLlSKFdYZ: for fun · https://t.co/nhOwk6R9Ug: BCtCI
Meder O @meder_o
3K Followers 8K Following https://t.co/29neLA6bjd | https://t.co/wrZS26Hr7E | https://t.co/38uPvjy3UH | https://t.co/XyeNWdoZkt
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Ian Banks @banksianr
668 Followers 777 Following @JoinFAI | Things I think about: science, politics, AI, ethics, the South, and Jesus | frmr: @c3solutionsNews @OU_TheoReligion @aei @covenantcollege | my own
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Lulu Cheng Meservey @lulumeservey
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David Piegaro @davidpiegaro
735 Followers 4K Following US Army Intel Veteran. Ex-Banker applying AI to rapidly scale and expand my family’s small children’s entertainment business.
Shelley Egan | @shell... @ShelleyEgan
2K Followers 4K Following Fiction and copy editor. Concerned about public health, transparency, accountability. Pls see @EganEditing for posts related to writing and editing.
Lucy @lucmahu3
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TedTheShredhead @ShredheadTed
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mcosta.eth —e/acc @Mcosta215
248 Followers 4K Following Founder at https://t.co/YmkWUbbQUn| ai/ml | blockchain | continuous learning | mountain sports 🏔️🧗🏽 | @hslu | @zhaw | @ucboulder
Sabuhi A. @SAbbaszad70856
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Hira @Hiraweb3
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Rory Jacobson @rorypjacobson
2K Followers 1K Following mostly congratulating my friends. views my own. He/him.
joovier @joovier8
237 Followers 2K Following Building | The course platform that builds an Al version of you Trader 📈| Investor YouTuber (1M+)
Ed Tate @dr_ed_tate
981 Followers 8K Following From cars, computers and batteries to software, satellites, and gigawatts. @Stanford | @UMich | PhD.
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Alex @alexrogu3
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TK @tomklein_
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Ash @arshiailaty
513 Followers 6K Following PhD @UCIrvine & @SDSU | EX-SWE-intern@Tesla گورستانِ ماه است شب!
Jesse D. Jenkins @JesseJenkins
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Jigar Shah @JigarShahDC
80K Followers 1K Following husband, dad, serial entrepreneur, podcaster, democratizing the electrostate by deploying at scale. It's simple, not easy.
Tim Latimer @TimMLatimer
32K Followers 2K Following CEO @fervoenergy, revolutionizing the electric grid with next-gen geothermal 🌋 ⚡️ Texan.
Jack Andreasen Cavana... @AndreasenJack
8K Followers 1K Following Carbon Upper Middle Management @columbiauenergy Senior Fellow @joinFAI
Nicole Kelner @NicoleKelner
18K Followers 1K Following I make art and mindful tech 💖 Author of Quietest Places in New York City 🗽 Founder of Free Time: the mindful screen-time app 🧘♀️ Climate artist 🌱
José Luis Ricón Fer... @ArtirKel
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Diego Saez Gil @dsaezgil
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nicole ruiz @nwilliams030
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whimsy lohan (in NYC) @SexyLikeMeiosis
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Eli Dourado @elidourado
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Ramez Naam @ramez
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Robert Höglund @RobertHoglund
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Nat Bullard @NatBullard
44K Followers 866 Following Energy systems and information platforms. @Halcyon, and priors @BloombergNEF, @climate, @VoyagerVC.
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Devon ☀️ @devonzuegel
59K Followers 1K Following I've gone to look for myself. If I return before I get back, please ask me to wait. Prev @GitHub @NotionHQ @Affirm @StanfordReview. Now building @Esmeralda_Inst
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138K Followers 3K Following I’m a software engineer at one of Canada’s top tech companies with really good TC. Internet veteran. (((Club Member))). Respectable account. 🇺🇸🇮🇱
Martin Bauer @martinmbauer
104K Followers 1K Following Working on particle physics, quantum sensors, dark matter. Associate Prof at @IPPP_Durham @durham_uni, FLF @UKRI_News, Science board member @STFC_Matters
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Crucible Capital @CrucibleCap
7K Followers 38 Following no thing is real but atoms in a void, and all things happen by chance and necessity
Midjourney @midjourney
459K Followers 0 Following A community supported research lab - exploring new mediums of thought and amplifying the imaginative powers of the human species.
Deena Mousa (SF June ... @deenamousa
3K Followers 540 Following Research & grantmaking @coeff_giving • Leave me anonymous feedback: https://t.co/0YmbLhCA2R
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Russell Newman 📚 A... @RussReadsBooks
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☉rthonormalist🧭�... @orthonormalist
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Paul Raymond-Robichau... @PaulRRobichaud
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BioGrid @BioGridGame
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Joanne Peng @JoanneZPeng
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Astrid Wilde 🌞 @astridwilde1
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Lisan al Gaib @scaling01
50K Followers 1K Following lead them to paradise LisanBench: https://t.co/vorVk7Oks6 Impressum & Datenschutz: https://t.co/lFLgiu9cqs
Neko Health @Neko
7K Followers 2 Following Stay ahead of your health with the Neko Health Scan. In Stockholm, London, Manchester & Birmingham – and soon, NYC.
Nostalgia @NostalgiaFolder
958K Followers 191 Following Posting nostalgic images and videos. DM for submissions #nostalgia #nostalgic
Shae McLaughlin @shae_mcl
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Reiner Pope @reinerpope
19K Followers 459 Following CEO and founder, @MatXComputing, developing high throughput chips tailored for LLMs
James Bradbury @jekbradbury
17K Followers 9K Following Compute at @AnthropicAI! Previously JAX, TPUs, and LLMs at Google, MetaMind/@SFResearch, @Stanford Linguistics, @Caixin.
Sid Sijbrandij @sytses
30K Followers 761 Following Co-founder & Executive Chair of GitLab. Co-founder of Kilo Code. I love economic mobility, remote work, new cities, big art, incentive design, and curing cancer
Sarah Constantin @s_r_constantin
2K Followers 443 Following (im)practical utopian. married to @oscredwin.



































