Everything that you wanted to know about glycomics in clinical science: @PLinkLenczowski presents his first-hand experience about the evaluation of glycans in cancer, autoimmune disorders, inflammation, CDGs, and neurodegenerative diseases. Must-read!
tinyurl.com/2ep55zfj
Engineered bacterial extracellular vesicles show promising anti-inflammatory and tissue-repairing effects in IBD. BEVs from L. plantarum may offer a new therapeutic path. - @UofMarylandexosome-rna.com/genetically-en…
Final published version of my student's paper on glycan remodelling and glycan arrays in @jbiolchem
Generating and probing NeuAc, NeuGc, GlcA, SO4 and Fuc epitopes, partly in combination, on N-glycan, lacto-tetraose or ganglioside scaffolds.
#glycotimejbc.org/article/S0021-…
A beautiful demonstration of individual genes producing multiple proteoforms with different subcellular localizations.
Alternative translation initiation sites generate N-terminally truncated proteoforms that localize to different cellular compartments.
Targeted protein degradation is a therapeutic strategy that entails hijacking a cell’s natural pathways for marking proteins for elimination.
In a new #ScienceReview, researchers look at recent advances that expand the range or targets, drug modalities, and control mechanisms, enabling promising therapeutic applications. scim.ag/3KmNI4S
Chemical modifications can improve the stability, efficiency and specificity of RNA therapeutics, while reducing their immunogenicity - find out more in this review
rdcu.be/eSyD6nature.com/articles/s4157…
Proteoglycan linkage region glycosyltransferases B4GalT7, B3GalT6, B3GlcAT-1 are dimeric and show promiscuity towards complex type N-glycans. B3GalT6 is a covalent dimer linked by a disulfide in the center of the large dimerization domain. tinyurl.com/vb2auutu#glycotime
For readers interested in approaches to improve the preclinical assessment of immunogenicity risk of engineered antibodies and other protein therapeutics, here's a recent review nature.com/articles/s4157…rdcu.be/enaiR
New review on structural glycobiology in glycosciences: "From enzymes to organelles". Carbohydrate processing enzymes, glycosylation networks in vitro, cryo-ET in direct visualisation of native biology.
tinyurl.com/4jnv85xt#glycotime
Interesting piece about glycosylated RNAs (glycoRNAs): sialylated glycoRNAs are present in human cell lines, and sialylation of glycoRNAs depends on the catalytic isoforms of the oligosaccharyltransferase (OST) complex.
tinyurl.com/vhz2rj8a
Protein sequencing is key to understanding cellular signalling pathways and metabolic processes. In their Review, @cees_dekker et al discuss how nanopores enable single-molecule protein sequencing and the identification of post-translational modifications
go.nature.com/40ZutV0
Now this is big! S. aureus vaccine exerts production of high levels of IL-10, resulting in the hyper-α2,3 sialylation of antibodies, which interfere with opsonophagocytic killing of S. aureus. Reviewed in tinyurl.com/2ubfanet, details in tinyurl.com/37hueffa#glycotime
84 Followers 551 Following11-13 June 2025 Maynooth University, Ireland 🇮🇪
The 16th Jenner Glycobiology and Medicine Conference welcomes you all to Maynooth University, Ireland.
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3K Followers 1K FollowingSNEV is a virtual network run by students interested in the extracellular vesicle field to connect EV research students internationally.
5K Followers 178 FollowingA new online-only journal from @NaturePortfolio publishing high-quality Reviews, Perspectives and Comments across all areas of bioengineering.
4K Followers 760 FollowingThe largest scientific society dedicated to extracellular vesicle research.
Our journals: @ISEV_Journals #JEV and #JExBio
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3K Followers 3K FollowingExosomes are cell-derived vesicles that are present in many and perhaps all biological fluids, including blood, urine, and cultured medium of cell cultures....
5K Followers 4K FollowingI study extracellular vesicles, enveloped viruses, and noncoding RNA. Johns Hopkins University, President of ISEV, host of EVClub, consultant
1K Followers 424 FollowingEVIta is a young society aimed at promoting basic, clinical and translational research and networking among researchers in the field of extracellular vesicles.
404 Followers 50 FollowingSuomen Solunulkoisten Vesikkelien Seura ry, twiitit englanniksi.
Finnish Society of Extracellular Vesicles, introducing EV research from Finland! #FISEV
2K Followers 2K FollowingVia this account, the editors of Extracell Vesicles Circ Nucleic Acids share new publications. Likes/retweets/follows do not endorse any particular viewpoint.
2K Followers 0 FollowingThe German Society for Extracellular Vesicles is the national network for scientists and professionals working in the field of exosomes, microvesicles and EVs.
1K Followers 495 FollowingThe Austrian Society for Extracellular Vesicles. Here to promote Austrian EV-science, to connect with our national sister societies and with ISEV
1K Followers 326 FollowingH2020 European Training Network focusing on exosomes & extracellular vesicles (EVs) in cancer. Led by Trinity College Dublin with PhD positions across Europe.
84 Followers 551 Following11-13 June 2025 Maynooth University, Ireland 🇮🇪
The 16th Jenner Glycobiology and Medicine Conference welcomes you all to Maynooth University, Ireland.
14K Followers 81 FollowingThe Mann Lab is a pioneer in mass spectrometry-based proteomics. Tweets represent personal views from lab members and Matthias Mann @MPI_Biochem and @UCPH_CPR.
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687 Followers 332 FollowingInterdisciplinary research team exploring the complexity of glycosylation and biological molecule interactions for patient well-being and societal impact