Crys Conn @CSConn_PhD
Assistant Prof @PennMedicine #RNA translation in cancer bio. Advocate for Science, Research, Healthy living & Equality #STEM #FirstGen #Fluid They/them CSConnLab.com Philadelphia, PA Joined April 2011-
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Crys Conn retweeted
We are recruiting a postdoc to work on an NIH funded project to determine the role of aging and oncogene-induced stromal senescence on prostate cancer initiation and therapy resistance. See job posting and recent publication below. ummsjobs.com/job/11591/ aacrjournals.org/cancerdiscover…
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Crys Conn retweeted
Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @Nature article demonstrates that these predictions miss thousands of protein sequences present in human tissues. Across >1,000 human samples, we identified numerous abundant proteins whose amino acid sequences differ from those predicted by the genetic code. These proteins are not rare translation byproducts. They accumulate to thousands of copies per cell. Some are more abundant than the proteins predicted by the genetic code from the same transcripts. Their abundance reflects a combination of alternate RNA decoding mechanisms — including codon-anticodon mismatches, tRNA abundance, and RNA modifications — and selective stabilization of the resulting proteins. The last factor – protein stability – emerges as a major determinant of protein abundance across proteins, proteoforms and cell types: slavovlab.net/research.htm#P… Alternate RNA decoding is pervasive across functional groups of proteins, healthy and diseased tissues. It affects proteins playing key roles in neurodegeneration, and some alternately decoded proteins show strong enrichment in tumors compared to their surrounding tissues. This discovery has been a long and exhilarating journey with Shira Tsour and the @slavovLab team. It started in 2019 and proceeded through many challenges and thrilling highs. A journey that has opened new perspectives that we long to explore! 1/
We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.110…
Crys Conn retweeted
Registration is now open for this very exciting Ribosome Heterogeneity and Translation Control meeting October 21-23rd @ScienceStowers . There will be open spots for talks. Please register! stowers.service-now.com/visitor?id=ove…
Crys Conn retweeted
Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes dlvr.it/TT6qrR
Crys Conn retweeted
Stress granules go viral: Molecular Cell cell.com/molecular-cell…
Fantastic work, congratulations to all involved!
Thanks you @RuggeroDavide for writing this piece in @jclinicalinvest highlighting Dr. Rashmi Mishra's work from @HsiehLab. Indeed, it is time to therapeutically target mRNA translation in cancer.
Crys Conn retweeted
Very nice resource paper in @Cancer_Cell that enables correlation of cell type specific expression data with survival in #PancreaticCancer. cell.com/cancer-cell/fu… Takes TCGA type datasets based on bulk RNA to the next level. Interactive web tool (ctPANDA) allows facile queries.
Crys Conn retweeted
TODAY! Pride Month Panel and Celebration @LTBGS_Penn @pennbgs @PennCDB @RTAatPennMed @PennBPP @PennMedicine
Crys Conn retweeted
Online Now: Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes dlvr.it/TSnkx0
Crys Conn retweeted
Join us for this year's Juneteenth Seminar with the one and only, Dr. Lydia Grmai @lydiagrmai from Yale School of Medicine. See details below. @PennMedicine
Crys Conn retweeted
Pride Month Panel and Celebration - June 8 @LTBGS_Penn @PennCDB @pennbgs @RTAatPennMed @PennBPP
Crys Conn retweeted
My lab is recruiting at the undergraduate volunteer and SRA level! Preference for candidates with protein purification experience. Please share, and see below for more details.
Crys Conn retweeted
Still time to send an abstract and register for the FASEB Cell Signaling in Cancer meeting. There are many speaking slots available for proffered abstracts, along with a fantastic lineup of speakers. Join us in Kentucky! events.faseb.org/event/Cell-Sig…
Crys Conn retweeted
Excited to share our collaborative work with the @TonyMustoe and @SuperSciJew labs, led by the fearless @RitwikaBose15. In this study, we developed RAID-MAP, an approach to map RNA structure within biomolecular condensates in living cells. biorxiv.org/content/10.648…
Crys Conn retweeted
Online Now: In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging dlvr.it/TSk9xH
First RNA Society! #RNA2026 Check out lab posters Friday: overview #329 #506 presented by Morgan McGrath and #507 by Nora Kiledjian
Crys Conn retweeted
Hi everyone! The Schug Lab is searching for a Lab Manager. If you are interested, please have a look through the job description and apply through the link below. This position is funded through new grant support. jeffersonhealth.wd5.myworkdayjobs.com/ThomasJefferso…
Crys Conn retweeted
In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging cell.com/molecular-cell…
Crys Conn retweeted
We have hundreds of PanINs in our pancreas, especially after age 40. They are a pre-cancerous lesion, but it is fortunately rare for one to progress to cancer (PDAC). Now we know a reason for that. The microenvironment. @umichmedicine @UMRogelCancer aacrjournals.org/cancerdiscover… @CD_AACR
Crys Conn retweeted
Very happy to see our study on the development of an in vivo single-cell ribosome profiling strategy for the epidermis now online at @MolecularCell. Fantastic work by @clarasdure and all co-authors involved. cell.com/molecular-cell…
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