Symptomatic primary EBV infection generates B cell subsets that gain access to the CNS, attract T cells and thereby initiate multiple sclerosis @Naturenature.com/articles/s4158…
Cancer cells can poison attacking immune cells by filling them with defective mitochondria ― dampening the body’s defensive forces and helping the tumour to evade eradication
go.nature.com/4jCBdzc
How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.110… 1/
Delivering and expressing a gene in cells is usually a messy (heterogeneous) process. The messiness interferes with research and applications such as gene therapy.
In two new papers, we introduce a toolbox of synthetic miRNA-based control circuits that enable more precise, gene dosage-invariant gene expression, and show how they improve a mouse model of Rett syndrome gene therapy:
biorxiv.org/content/10.110… ,led by @RongrongDu123 and @MichaelJAFlynnbiorxiv.org/content/10.110… , led by @MichaelJAFlynn and Acacia Mayfield, in collaboration with Viviana Gradinaru.
How does retinoic acid regulate lineage plasticity in hair follicle stem cells? Read all about it in our paper out today @ScienceMagazine by @tierney788 and co-authors. Congratulations for this outstanding work 👏🏼
science.org/doi/10.1126/sc…
open access link to our paper. We prove: 1. immune cells can prevent cancer, and 2. Mutated cells must turn immune silent to grow cancer, here with a fetal reprogramming. With gut stem cell expert @ohyilmaz and me as the immune evasion expert secure-web.cisco.com/1BU72ZRw5WM4am…
Next monday is 4 hours of preliminary grant reviews - a necessary but intense part of being a scientist who goes through peer review is being the reviewer. As ever, I am rather amazed by scientists who make simple mistakes in their proposals. My thoughts for a good proposal:
898 Followers 636 FollowingPhysician-scientist, derm, epithelial/cancer bio, single-cell and spatial genomics, PI of Ji Lab @IcahnMountSinai | Tweets my own
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126 Followers 134 FollowingMedical researcher at Osaka International Cancer Institute, Japan
FRET, ERK signal, SPREAD, Human keratinocytes, Pancreas organoid, and some Jython scripting.
181 Followers 1K FollowingPhD candidate @OSheaHoganLab, @IrishResearch funded examining the effects of GLP-1 therapy on NK cells | likes to bake and throwing flat discs.
289 Followers 332 FollowingPostdoc in @teichlab at @Cambridge_Uni. Interest in immune and vascular biology, bioinformatics, personalised medicine, organoids, stem cells.
94 Followers 121 FollowingIeva Beržanskytė is an MRC Postdoc at MRC Laboratory of Molecular Biology in Cambridge, working on direct cell reprogramming using Mogrify
3K Followers 1K Followingthe Laboratory of Lymphatic Immunobiology - exploring the contribution of lymphatic transport to dermal and anti-tumor immunity @nyulangone
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111 Followers 115 FollowingInterested in development and regeneration of CNS. PhD in @NEURODEVOGROUP, then PostDoc in @UCLeye and now PostDoc studying SC regeneration in @BeckerLabCRTD 😊
1.8M Followers 0 FollowingA “mordant celebration of British mediocrity” according to the Washington Post. Contains sarcasm, irony and context. Blocked by John Cleese.
9K Followers 183 FollowingProfessor at Harvard Medical School, in love with a red-haired beautiful woman, his kids... and immunology. He/him/his. 🇮🇹 🇺🇸 Views my own.
31K Followers 5K FollowingAdvancing cancer immunotherapy through research, collaboration and data-driven innovation. Creating a world #Immune2Cancer. Est. 1953.
741 Followers 240 FollowingContinuing the legacy of our inaugural director Paul S. Frenette.
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3K Followers 2K FollowingA translational research lab @MSKCancerCenter focused on the immunobiology and therapeutic potential of genetically engineered #Tcells and #TCRs. Est.2016 @NYC.
39K Followers 1K FollowingEMBO is the organization of more than 2,200 leading researchers that promotes excellence in life sciences in Europe and beyond
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16K Followers 352 FollowingWhitehead Institute is a world-renowned, non-profit scientific institution dedicated to improving human health through basic biomedical research.
835 Followers 536 FollowingThe ‘LEO Foundation Skin Immunology Research Center’ paves the way to a better treatment of the skin diseases that plague a quarter of the world.
387 Followers 61 Following#Dermatologist and scientist at @UCSF and founder of Trex Bio. My lab studies #Treg biology and #skinimmunology in mice and humans.
9K Followers 1K Following@eLife works with researchers across the globe to promote openness, integrity, equity, diversity and inclusion in research culture. @eLifeCommunity.bsky.social
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28K Followers 2K FollowingThe Wyss Institute seeks to transform engineering, medicine and the environment by creating new materials and devices using Nature’s design principles.
1K Followers 543 FollowingOne of the largest private funders globally of independent skin research. Providing philanthropic grants to support the best international research.
23K Followers 916 FollowingThe Peter Doherty Institute for Infection and Immunity at @UniMelbMDHS @theRMH. Research includes #HIV, #hepatitis, #malaria, #influenza #COVID19 & more.
898 Followers 636 FollowingPhysician-scientist, derm, epithelial/cancer bio, single-cell and spatial genomics, PI of Ji Lab @IcahnMountSinai | Tweets my own